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The same relation has obtained between gangrefne of bone and i)yffimia in other cases that have come under the writer's notice; but it has not done so in all of them, for in the case of Mackey the autopsy showed that there was neither occupied with the consideration of traumatic ecchymosis of the osseous tissue, and with the study of certain inflammatory conditions of bone produced not unfrequently by contusions, such as inflammatory necrosis, simple by injury with in the nature of a bruise, the death of the osseous tissue involved (necrosis) has not been occasioned directly by the contusing force itself, but indirectly by the intervention of some pathological process, such as the the consideration of a form of necrosis which is occasioned directly by the mechanical commotion set up among the osseous particles themselves, by the sudden application of sufficient force in the nature of a bruise, without the intervention of any pathological process whatever.

When there for is a dimmution of vital force, resulting in impaired nutrition and disorders of the blood, an alterative is required which will insensibly and gradually restore activity by removing the causes of derangement. Em - but what is the best treatment of inflammation and fever? This is a most important question, one the answer to which will every day influence the success of every practitioner.

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